The Arsenal youth product has been battling through injury for the past five years and doesn't want to carry on playing through the pain.
Despite the lengthy time Frimpong spent around the Emirates, he only made six first team appearances under Arsene Wenger who touted him as a huge prospect.
In a statement on twitter Frimpong said: "It is with great sadness I have decided to retire from professional football,"
"I have had problems with my knee for the last five years or so and have got back to playing at a professional level.
"But since November 2017 I haven't been in action as I had a tear in my knee ligament.
"I decided with my own will that I will not opt for the operation since I was not enjoying football playing through pain.
The tear in Frimpong's knee came after spells in Russia, Sweden and Cyprus with the Ghanaian ending his career as a free agent.
He added: "I would love to thank all the clubs I have represented, Arsenal, Charlton, Barnsley, Fulham, Ufa, AFC Eskilstuna and Ermis for the love and support they have given and to the fans who always supported me. Thank you and let's see what the future holds.
"Spending time with my daughter and family the last year has made me realise I'm blessed."
Former Arsenal team-mate Jack Wilshere, who came through the acadamy with Frimpong, wished him the best during his retirement in response on twitter.
Arsenal fans will also remember Frimpong's catchphrase 'Dench', which he and his rapper cousin Lethal Bizzle coined whilst playing video games.
Whether in Bizzle's music or on the back of Frimpong's shirt when he played in Russia, the catchphrase caught on and eventually transformed into a successful clothing brand.
Lethal Bizzle did take to Instagram to thank the footballer and wish him luck in the future.
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