The Cherries are in advanced negotiations to sign the Bees defender.
That follows three failed attempts to sign him in the last three windows.
Southampton are also keen on Mepham.
But Howe’s continued faith in the Welshman, as revealed exclusively in SunSport yesterday, means he only desires a move to the Vitality Stadium.
Bournemouth see landing the 21-year-old at long last as a big coup that will strengthen Howe’s central defensive options.
Their versatile captain Simon Francis is sidelined through long-term injury and they want reinforcements.
Mepham has already played four times for Wales is tipped to become a top defender in the future.
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He would be Bournemouth’s third signing of a busy January transfer window so far.
Howe has already taken Dominic Solanke and Nathaniel Clyne from Liverpool for £19million and on loan respectively.
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